Decode your aging story to shape what comes next
By measuring key biomarkers of immune aging, you can uncover the biological imprint of your past and the real-time effects of your current routines and practices.
Emerging Evidence. Enduring Impact
Emerging scientific research highlights the immune system as a central regulator of healthspan.
Among all mammalian species, immune function shows one of the strongest correlations with longevity.
The ability to suppress chronic inflammation and withstand infections are central features of healthy aging in humans, including in super-centenarians.
Greater immune resilience has been associated with up to 15 additional years of life, underscoring the immune system’s central role in healthy aging.
Stop guessing. Start measuring. Age smarter.
Immune resilience is shaped by many factors including exercise, nutrition, sleep, genetics, environmental exposures, recent and previous infections, and health practices. Because it’s shaped by so many inputs, it’s also one of the most dynamic and modifiable systems in your body. Results can be highly heterogeneous, varying widely from person to person.
Two people who appear similar can have vastly different immune resilience profiles
Each Domain Holds Clues
The SapereX hexagon shows how optimized you are in each immune domain. Your full report dives deeper into each domain to show where you stand in a large population actively optimizing for longevity.
SENESCENCE
Very low senescent cell load and coupled with a robust immune system suggests an excellent aging trajectory
SENESCENCE
Very low senescent cell load and coupled with a robust immune system suggests an excellent aging trajectory
SENESCENCE
Very low senescent cell load and coupled with a robust immune system suggests an excellent aging trajectory
One of the most talked - about metrics in longevity science is cellular senescence—a major driver of immune aging, healthspan, and overall longevity.
Research shows that reducing senescent cells can slow aging - related decline, while their accumulation accelerates it.
As more people explore ways to modulate senescence, understanding your own levels can help you determine whether this is a priority area for your longevity strategy.
Discover Where You Stand
How have my history and current longevity practices impacted my immune resilience?
Are my immune resilience biomarkers optimized?
Which domain(s) show the greatest opportunity for improvement?
Monitor Your Progress
What changes have occurred in my biomarkers following recent interventions?
Do my results indicate progress in the right direction?
How have my biomarkers shifted in response to recent health challenges?
What Do SapereX Longevity Physician Customers Say?
"Sapere Bio has amassed a good amount of compelling clinical use data. We've been using the test in our clinical program and I'm impressed with the results, especially compared to other biological aging' tests out there"
"So many people are going on rapamycin and various other therapies without really knowing whether they're really good candidates for it. I think SapereX is a really important way to practice evidence-based longevity medicine"
"SapereX is a much-needed tool to assess patients for their candidacy for and the effectiveness of many of the emerging longevity therapies"
Get Access to SapereX Longevity
Peer-Reviewed Literature
- Mylonas A, O'Loghlen A. Cellular Senescence and Ageing: Mechanisms and Interventions. Front Aging. 2022;3.
- Baker DJ, Childs BG, Durik M, et al. Naturally occurring p16 Ink4a-positive cells shorten healthy lifespan. Nature. 2016;530(7589).
- McHugh D, Gil J. Senescence and aging: Causes, consequences, and therapeutic avenues. Journal of Cell Biology. 2017;217(1):65-77.
- Delgado-Pulido S, Yousefzadeh MJ,Mittelbrunn M. Aging reshapes the adaptive immune system from healer to saboteur. Nat Aging. 2025;5(8):1393-1403.
- Liu Y, Sanoff HK, Cho H, et al.Expression of p16 INK4a in peripheral blood T-cells is a biomarker of humanaging. Aging Cell. 2009;8(4):439-448.
- Xu W, Larbi A. Markers of T cellsenescence in humans. International Journal of Molecular Sciences.2017;18(8):1-13.
- Yousefzadeh MJ, Flores RR, Zhu Y, et al. An aged immune systemdrives senescence and ageing of solid organs. Nature. 2021;594(7861):100-105.
- Chen HA, Ho YJ, Mezzadra R, et al. Senescence RewiresMicroenvironment Sensing to Facilitate Antitumor Immunity. Cancer Discovery.2023;13(2):432-453.
- Manoharan MS, Lee GC, Harper N, et al. The 15-Year SurvivalAdvantage: Immune Resilience as a Salutogenic Force in Healthy Aging. AgingCell.
- McLane LM, Abdel-Hakeem MS, WherryEJ. CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. AnnualReview of Immunology. 2019;37:457-495.